A novel method for detection of exfoliated prostate cancer cells in urine by RNA in situ hybridization.

Jillian N EskraDaniel RabizadehLeslie MangoldElizabeth FabianW Nathaniel BrennenDavid B YeaterKenneth J PientaAlan W PartinWilliam B IsaacsChristian P PavlovichJun Luo

Published in: Prostate cancer and prostatic diseases (2020)

Multiplex RISH enables the direct visualization and molecular characterization of individual exfoliated prostate cells in urine. This proof-of-principle study provides evidence supporting the application of RISH as a potential noninvasive tool for prostate cancer detection.

Keyphrases

prostate cancer
real time pcr
induced apoptosis
loop mediated isothermal amplification
radical prostatectomy
label free
cell cycle arrest
oxidative stress
cell death
cell proliferation
benign prostatic hyperplasia
human health
climate change
electron microscopy