W Nathaniel Brennen (W N Brennen)

Publication Activity (10 Years)

Years Active: 2018-2024
Publications (10 Years): 39

Top Topics

Benign Prostatic Hyperplasia

Structural Basis

Radical Prostatectomy

Top Venues

Cancer discovery

Stem cells translational medicine

Molecular cancer therapeutics

This page only lists publications with an associated author ORCID identifier.

Publications

Mary M Stangis, Zhengyi Chen, Jimin Min, Sarah E Glass, Jordan O Jackson, Megan D Radyk, Xen Ping Hoi, W Nathaniel Brennen, Ming Yu, Huy Q Dinh, D Borden Lacy, Martha J Shrubsole, Keith Syson Chan, William M Grady, Srinivasan Yegnasubramanian, Costas Andreas Lyssiotis, Anirban Maitra, Richard B Halberg, Neelendu Dey, Ken S Lau
The Hallmarks of Precancer. Cancer discovery 14 (4) (2024)
Mary M Stangis, Zhengyi Chen, Jimin Min, Sarah E Glass, Jordan O Jackson, Megan D Radyk, Xen Ping Hoi, W Nathaniel Brennen, Ming Yu, Huy Q Dinh, D Borden Lacy, Martha J Shrubsole, Keith Syson Chan, William M Grady, Srinivasan Yegnasubramanian, Costas Andreas Lyssiotis, Anirban Maitra, Richard B Halberg, Neelendu Dey, Ken S Lau
The Hallmarks of Precancer. Cancer discovery 14 (4) (2024)
W Nathaniel Brennen, Clémentine Le Magnen, Sofia Karkampouna, Nicolas Anselmino, Nathalie Bock, Nicholas Choo, Ashlee K Clark, Ilsa M Coleman, Robin Dolgos, Alison M Ferguson, David L Goode, Marianna Krutihof-de Julio, Nora M Navone, Peter S Nelson, Edward O'Neill, Laura H Porter, Weranja Ranasinghe, Takuro Sunada, Elizabeth D Williams, Lisa M Butler, Eva Corey, Wytske M van Weerden, Renea A Taylor, Gail P Risbridger, Mitchell G Lawrence
Defining the challenges and opportunities for using patient-derived models in prostate cancer research. The Prostate 84 (7) (2024)
Mary M Stangis, Zhengyi Chen, Jimin Min, Sarah E Glass, Jordan O Jackson, Megan D Radyk, Xen Ping Hoi, W Nathaniel Brennen, Ming Yu, Huy Q Dinh, D Borden Lacy, Martha J Shrubsole, Keith Syson Chan, William M Grady, Srinivasan Yegnasubramanian, Costas Andreas Lyssiotis, Anirban Maitra, Richard B Halberg, Neelendu Dey, Ken S Lau
The Hallmarks of Precancer. Cancer discovery 14 (4) (2024)
Mary M Stangis, Zhengyi Chen, Jimin Min, Sarah E Glass, Jordan O Jackson, Megan D Radyk, Xen Ping Hoi, W Nathaniel Brennen, Ming Yu, Huy Q Dinh, D Borden Lacy, Martha J Shrubsole, Keith Syson Chan, William M Grady, Srinivasan Yegnasubramanian, Costas Andreas Lyssiotis, Anirban Maitra, Richard B Halberg, Neelendu Dey, Ken S Lau
The Hallmarks of Precancer. Cancer discovery 14 (4) (2024)
W Nathaniel Brennen, Clémentine Le Magnen, Sofia Karkampouna, Nicolas Anselmino, Nathalie Bock, Nicholas Choo, Ashlee K Clark, Ilsa M Coleman, Robin Dolgos, Alison M Ferguson, David L Goode, Marianna Krutihof-de Julio, Nora M Navone, Peter S Nelson, Edward O'Neill, Laura H Porter, Weranja Ranasinghe, Takuro Sunada, Elizabeth D Williams, Lisa M Butler, Eva Corey, Wytske M van Weerden, Renea A Taylor, Gail P Risbridger, Mitchell G Lawrence
Defining the challenges and opportunities for using patient-derived models in prostate cancer research. The Prostate (2024)
Sumer Jasmine, Adel Mandl, Timothy E G Krueger, Susan L Dalrymple, Lizamma Antony, Jennifer Dias, Cassandra A Celatka, Amy E Tapper, Maria Kleppe, Mayuko Kanayama, Yuezhou Jing, Valentina Speranzini, Yuzhuo Z Wang, Jun Luo, Bruce J Trock, Samuel R Denmeade, Michael A Carducci, Andrea Mattevi, Hugh Y Rienhoff, John T Isaacs, W Nathaniel Brennen
Characterization of structural, biochemical, pharmacokinetic, and pharmacodynamic properties of the LSD1 inhibitor bomedemstat in preclinical models. The Prostate (2024)
Mannan Nouri, Andreas Varkaris, Maya Ridinger, Susan L Dalrymple, Christopher M Dennehy, John T Isaacs, David J Einstein, W Nathaniel Brennen, Steven P Balk
AKT Inhibition Sensitizes to Polo-Like Kinase 1 Inhibitor Onvansertib in Prostate Cancer. Molecular cancer therapeutics (2024)
A Mandl, S Jasmine, Teg Krueger, R Kumar, I M Coleman, S L Dalrymple, L Antony, D M Rosen, Y Jing, B Hanratty, R A Patel, L Jin-Yih, J Dias, C A Celatka, A E Tapper, M Kleppe, M Kanayama, V Speranzini, Y Z Wang, J Luo, E Corey, L A Sena, R A Casero, T Lotan, B J Trock, S K Kachhap, S R Denmeade, M A Carducci, A Mattevi, M C Haffner, P S Nelson, H Y Rienhoff, J T Isaacs, W Nathaniel Brennen
LSD1 inhibition suppresses ASCL1 and de-represses YAP1 to drive potent activity against neuroendocrine prostate cancer. bioRxiv : the preprint server for biology (2024)
Mannan Nouri, Andreas Varkaris, Maya Ridinger, Susan L Dalrymple, Christopher M Dennehy, John T Isaacs, David J Einstein, W Nathaniel Brennen, Steven P Balk
AKT Inhibition Sensitizes to Polo-Like Kinase 1 Inhibitor Onvansertib in Prostate Cancer. Molecular cancer therapeutics (2024)
W Nathaniel Brennen, Clémentine Le Magnen, Sofia Karkampouna, Nicolas Anselmino, Nathalie Bock, Nicholas Choo, Ashlee K Clark, Ilsa M Coleman, Robin Dolgos, Alison M Ferguson, David L Goode, Marianna Krutihof-de Julio, Nora M Navone, Peter S Nelson, Edward O'Neill, Laura H Porter, Weranja Ranasinghe, Takuro Sunada, Elizabeth D Williams, Lisa M Butler, Eva Corey, Wytske M van Weerden, Renea A Taylor, Gail P Risbridger, Mitchell G Lawrence
Defining the challenges and opportunities for using patient-derived models in prostate cancer research. The Prostate 84 (7) (2024)
Sumer Jasmine, Adel Mandl, Timothy E G Krueger, Susan L Dalrymple, Lizamma Antony, Jennifer Dias, Cassandra A Celatka, Amy E Tapper, Maria Kleppe, Mayuko Kanayama, Yuezhou Jing, Valentina Speranzini, Yuzhuo Z Wang, Jun Luo, Bruce J Trock, Samuel R Denmeade, Michael A Carducci, Andrea Mattevi, Hugh Y Rienhoff, John T Isaacs, W Nathaniel Brennen
Characterization of structural, biochemical, pharmacokinetic, and pharmacodynamic properties of the LSD1 inhibitor bomedemstat in preclinical models. The Prostate 84 (10) (2024)
W Nathaniel Brennen, Clémentine Le Magnen, Sofia Karkampouna, Nicolas Anselmino, Nathalie Bock, Nicholas Choo, Ashlee K Clark, Ilsa M Coleman, Robin Dolgos, Alison M Ferguson, David L Goode, Marianna Krutihof-de Julio, Nora M Navone, Peter S Nelson, Edward O'Neill, Laura H Porter, Weranja Ranasinghe, Takuro Sunada, Elizabeth D Williams, Lisa M Butler, Eva Corey, Wytske M van Weerden, Renea A Taylor, Gail P Risbridger, Mitchell G Lawrence
Defining the challenges and opportunities for using patient-derived models in prostate cancer research. The Prostate 84 (7) (2024)
Sumer Jasmine, Adel Mandl, Timothy E G Krueger, Susan L Dalrymple, Lizamma Antony, Jennifer Dias, Cassandra A Celatka, Amy E Tapper, Maria Kleppe, Mayuko Kanayama, Yuezhou Jing, Valentina Speranzini, Yuzhuo Z Wang, Jun Luo, Bruce J Trock, Samuel R Denmeade, Michael A Carducci, Andrea Mattevi, Hugh Y Rienhoff, John T Isaacs, W Nathaniel Brennen
Characterization of structural, biochemical, pharmacokinetic, and pharmacodynamic properties of the LSD1 inhibitor bomedemstat in preclinical models. The Prostate 84 (10) (2024)
Sumer Jasmine, Adel Mandl, Timothy E G Krueger, Susan L Dalrymple, Lizamma Antony, Jennifer Dias, Cassandra A Celatka, Amy E Tapper, Maria Kleppe, Mayuko Kanayama, Yuezhou Jing, Valentina Speranzini, Yuzhuo Z Wang, Jun Luo, Bruce J Trock, Samuel R Denmeade, Michael A Carducci, Andrea Mattevi, Hugh Y Rienhoff, John T Isaacs, W Nathaniel Brennen
Characterization of structural, biochemical, pharmacokinetic, and pharmacodynamic properties of the LSD1 inhibitor bomedemstat in preclinical models. The Prostate (2024)
W Nathaniel Brennen, Clémentine Le Magnen, Sofia Karkampouna, Nicolas Anselmino, Nathalie Bock, Nicholas Choo, Ashlee K Clark, Ilsa M Coleman, Robin Dolgos, Alison M Ferguson, David L Goode, Marianna Krutihof-de Julio, Nora M Navone, Peter S Nelson, Edward O'Neill, Laura H Porter, Weranja Ranasinghe, Takuro Sunada, Elizabeth D Williams, Lisa M Butler, Eva Corey, Wytske M van Weerden, Renea A Taylor, Gail P Risbridger, Mitchell G Lawrence
Defining the challenges and opportunities for using patient-derived models in prostate cancer research. The Prostate 84 (7) (2024)
W Nathaniel Brennen, Clémentine Le Magnen, Sofia Karkampouna, Nicolas Anselmino, Nathalie Bock, Nicholas Choo, Ashlee K Clark, Ilsa M Coleman, Robin Dolgos, Alison M Ferguson, David L Goode, Marianna Krutihof-de Julio, Nora M Navone, Peter S Nelson, Edward O'Neill, Laura H Porter, Weranja Ranasinghe, Takuro Sunada, Elizabeth D Williams, Lisa M Butler, Eva Corey, Wytske M van Weerden, Renea A Taylor, Gail P Risbridger, Mitchell G Lawrence
Defining the challenges and opportunities for using patient-derived models in prostate cancer research. The Prostate 84 (7) (2024)
Mary M Stangis, Zhengyi Chen, Jimin Min, Sarah E Glass, Jordan O Jackson, Megan D Radyk, Xen Ping Hoi, W Nathaniel Brennen, Ming Yu, Huy Q Dinh, D Borden Lacy, Martha J Shrubsole, Keith Syson Chan, William M Grady, Srinivasan Yegnasubramanian, Costas Andreas Lyssiotis, Anirban Maitra, Richard B Halberg, Neelendu Dey, Ken S Lau
The Hallmarks of Precancer. Cancer discovery 14 (4) (2024)
Sumer Jasmine, Adel Mandl, Timothy E G Krueger, Susan L Dalrymple, Lizamma Antony, Jennifer Dias, Cassandra A Celatka, Amy E Tapper, Maria Kleppe, Mayuko Kanayama, Yuezhou Jing, Valentina Speranzini, Yuzhuo Z Wang, Jun Luo, Bruce J Trock, Samuel R Denmeade, Michael A Carducci, Andrea Mattevi, Hugh Y Rienhoff, John T Isaacs, W Nathaniel Brennen
Characterization of structural, biochemical, pharmacokinetic, and pharmacodynamic properties of the LSD1 inhibitor bomedemstat in preclinical models. The Prostate 84 (10) (2024)
W Nathaniel Brennen, Clémentine Le Magnen, Sofia Karkampouna, Nicolas Anselmino, Nathalie Bock, Nicholas Choo, Ashlee K Clark, Ilsa M Coleman, Robin Dolgos, Alison M Ferguson, David L Goode, Marianna Krutihof-de Julio, Nora M Navone, Peter S Nelson, Edward O'Neill, Laura H Porter, Weranja Ranasinghe, Takuro Sunada, Elizabeth D Williams, Lisa M Butler, Eva Corey, Wytske M van Weerden, Renea A Taylor, Gail P Risbridger, Mitchell G Lawrence
Defining the challenges and opportunities for using patient-derived models in prostate cancer research. The Prostate 84 (7) (2024)
Mary M Stangis, Zhengyi Chen, Jimin Min, Sarah E Glass, Jordan O Jackson, Megan D Radyk, Xen Ping Hoi, W Nathaniel Brennen, Ming Yu, Huy Q Dinh, D Borden Lacy, Martha J Shrubsole, Keith Syson Chan, William M Grady, Srinivasan Yegnasubramanian, Costas Andreas Lyssiotis, Anirban Maitra, Richard B Halberg, Neelendu Dey, Ken S Lau
The Hallmarks of Precancer. Cancer discovery 14 (4) (2024)
Peng Lu, Karolyn A Oetjen, Diane E Bender, Marianna B Ruzinova, Daniel A C Fisher, Kevin G Shim, Russell K Pachynski, W Nathaniel Brennen, Stephen T Oh, Daniel C Link, Daniel L J Thorek
IMC-Denoise: a content aware denoising pipeline to enhance Imaging Mass Cytometry. Nature communications 14 (1) (2023)
Mark P Labrecque, Lisha G Brown, Ilsa M Coleman, Holly M Nguyen, Susan Dalrymple, W Nathaniel Brennen, John T Isaacs, Dapei Li, Bryce Lakely, Diana C DeLucia, John K Lee, Michael T Schweizer, Daniel W Lin, Eva Corey, Peter S Nelson, Colm Morrissey
Targeting the fibroblast growth factor pathway in molecular subtypes of castration-resistant prostate cancer. The Prostate (2023)
Joakin O Mori, Isra Elhussin, W Nathaniel Brennen, Mindy K Graham, Tamara L Lotan, Clayton C Yates, Angelo M DeMarzo, Samuel R Denmeade, Srinivasan Yegnasubramanian, William G Nelson, Gerald V Denis, Elizabeth A Platz, Alan K Meeker, Christopher M Heaphy
Prognostic and therapeutic potential of senescent stromal fibroblasts in prostate cancer. Nature reviews. Urology (2023)
John T Isaacs, Susan L Dalrymple, Lizamma Antony, David Marc Rosen, Ilsa M Coleman, Peter S Nelson, Maya Kostova, Iain A Murray, Gary H Perdew, Samuel R Denmeade, Emmanuel S Akinboye, W Nathaniel Brennen
Third generation quinoline-3-carboxamide transcriptional disrupter of HDAC4, HIF-1α, and MEF-2 signaling for metastatic castration-resistant prostate cancer. The Prostate (2023)
Laura A Sena, W Nathaniel Brennen, John T Isaacs
There are gremlins in prostate cancer. Nature cancer 3 (5) (2022)
Rajendra Kumar, Janet Mendonca, Olutosin Owoyemi, Kavya Boyapati, Naiju Thomas, Suthicha Kanacharoen, Max Coffey, Deven Topiwala, Carolina Gomes, Busra Ozbek, Tracy Jones, Marc Rosen, Liang Dong, Sadie Wiens, W Nathaniel Brennen, John T Isaacs, Angelo M DeMarzo, Mark C Markowski, Emmanuel S Antonarakis, David Z Qian, Kenneth J Pienta, Drew M Pardoll, Michael A Carducci, Samuel R Denmeade, Sushant K Kachhap
Supraphysiologic Testosterone Induces Ferroptosis and Activates Immune Pathways through Nucleophagy in Prostate Cancer. Cancer research 81 (23) (2021)
Amber E de Groot, Kayla V Myers Chen, Timothy E G Krueger, Ashley L Kiemen, Natalia H Nagy, Alexandria Brame, Vicente E Torres, Zhongyuan Zhang, Levent Trabzonlu, W Nathaniel Brennen, Denis Wirtz, Angelo M De Marzo, Sarah R Amend, Kenneth J Pienta
Characterization of tumor-associated macrophages in prostate cancer transgenic mouse models. The Prostate 81 (10) (2021)
Jillian N Eskra, Daniel Rabizadeh, Leslie Mangold, Elizabeth Fabian, W Nathaniel Brennen, David B Yeater, Kenneth J Pienta, Alan W Partin, William B Isaacs, Christian P Pavlovich, Jun Luo
A novel method for detection of exfoliated prostate cancer cells in urine by RNA in situ hybridization. Prostate cancer and prostatic diseases 24 (1) (2020)
Oliver C Rogers, Lizamma Antony, Oren Levy, Nitin Joshi, Brian W Simons, Susan L Dalrymple, D Marc Rosen, Andrew J Pickering, Haoyue Lan, Heidi Kuang, Sudhir H Ranganath, Lei Zheng, Jeffrey M Karp, S Peter Howard, Samuel R Denmeade, John T Isaacs, W Nathaniel Brennen
Microparticle Encapsulation of a Prostate-targeted Biologic for the Treatment of Liver Metastases in a Preclinical Model of Castration-resistant Prostate Cancer. Molecular cancer therapeutics 19 (11) (2020)
Yezi Zhu, Susan L Dalrymple, Ilsa Coleman, S Lilly Zheng, Jianfeng Xu, Jody E Hooper, Emmanuel S Antonarakis, Angelo M De Marzo, Alan K Meeker, Peter S Nelson, William B Isaacs, Samuel R Denmeade, Jun Luo, W Nathaniel Brennen, John T Isaacs
Role of androgen receptor splice variant-7 (AR-V7) in prostate cancer resistance to 2nd-generation androgen receptor signaling inhibitors. Oncogene 39 (45) (2020)
Jin-Yih Low, W Nathaniel Brennen, Alan K Meeker, Elina Ikonen, Brian W Simons, Marikki Laiho
Stromal CAVIN1 Controls Prostate Cancer Microenvironment and Metastasis by Modulating Lipid Distribution and Inflammatory Signaling. Molecular cancer research : MCR 18 (9) (2020)
Brian W Simons, Susan Dalrymple, Marc Rosen, Lei Zheng, W Nathaniel Brennen
A hemi-spleen injection model of liver metastasis for prostate cancer. The Prostate 80 (14) (2020)
W Nathaniel Brennen, Daniel L J Thorek, Wen Jiang, Timothy E G Krueger, Lizamma Antony, Samuel R Denmeade, John T Isaacs
Overcoming stromal barriers to immuno-oncological responses via fibroblast activation protein-targeted therapy. Immunotherapy 13 (2) (2020)
Robert M Hughes, Brian W Simons, Hamda Khan, Rebecca Miller, Valentina Kugler, Samantha Torquato, Debebe Theodros, Michael C Haffner, Tamara Lotan, Jessie Huang, Elai Davicioni, Steven S An, Ryan C Riddle, Daniel L J Thorek, Isla P Garraway, Elana J Fertig, John T Isaacs, W Nathaniel Brennen, Ben H Park, Paula J Hurley
Asporin Restricts Mesenchymal Stromal Cell Differentiation, Alters the Tumor Microenvironment, and Drives Metastatic Progression. Cancer research 79 (14) (2019)
W Nathaniel Brennen, Michael Thomas Schweizer, Hao Wang, Trinity J Bivalacqua, Alan W Partin, Su Jin Lim, Carolyn Chapman, Rehab Abdallah, Oren Levy, Neil A Bhowmick, Jeffrey M Karp, Angelo De Marzo, John T Isaacs, Samuel R Denmeade
In Reply. Stem cells translational medicine 8 (7) (2019)
Michael Thomas Schweizer, Hao Wang, Trinity J Bivalacqua, Alan W Partin, Su Jin Lim, Carolyn Chapman, Rehab Abdallah, Oren Levy, Neil A Bhowmick, Jeffrey M Karp, Angelo De Marzo, John T Isaacs, W Nathaniel Brennen, Samuel R Denmeade
A Phase I Study to Assess the Safety and Cancer-Homing Ability of Allogeneic Bone Marrow-Derived Mesenchymal Stem Cells in Men with Localized Prostate Cancer. Stem cells translational medicine 8 (5) (2019)
Timothy E G Krueger, Daniel L J Thorek, Samuel R Denmeade, John T Isaacs, W Nathaniel Brennen
Concise Review: Mesenchymal Stem Cell-Based Drug Delivery: The Good, the Bad, the Ugly, and the Promise. Stem cells translational medicine 7 (9) (2018)
Timothy E Krueger, Daniel L J Thorek, Alan K Meeker, John T Isaacs, W Nathaniel Brennen
Tumor-infiltrating mesenchymal stem cells: Drivers of the immunosuppressive tumor microenvironment in prostate cancer? The Prostate 79 (3) (2018)