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Intrapatient comparison of atopic dermatitis skin transcriptome shows differences between tape-strips and biopsies.

Ester Del DucaHelen HeYing LiuAngel D PaganEden M GriffinJulia ChengBritta CarrollYael Renert-YuvalJohnathan BarYeriel D EstradaCatherine MaariEtienne Saint-Cyr ProulxJames G KruegerRobert BissonnetteEmma Guttman-Yassky
Published in: Allergy (2023)
Tape-strips and biopsies capture overlapping but distinct features of the AD molecular signature, suggesting their respective utility for monitoring specific AD-related immune, itch, and barrier abnormalities in clinical trials and longitudinal studies.
Keyphrases
  • atopic dermatitis
  • clinical trial
  • ultrasound guided
  • gene expression
  • rna seq
  • single cell
  • genome wide
  • soft tissue
  • cross sectional
  • wound healing
  • case control
  • phase ii
  • dna methylation
  • study protocol
  • drug induced