The lncRNA XIST/miR-125b-2-3p axis modulates cell proliferation and chemotherapeutic sensitivity via targeting Wee1 in colorectal cancer.
Zhao-Lei ZengJia-Huan LuYun WangHui ShengYing-Nan WangZhan-Hong ChenQi-Nian WuJia-Bo ZhengYan-Xing ChenDong-Dong YangKai YuHai-Yu MoJia-Jia HuPei-Shan HuZe-Xian LiuHuai-Qiang JuRui-Hua XuPublished in: Cancer medicine (2021)
Lower miR-125b-2-3p expression resulted in lower sensitivity of CRC to chemotherapy and was correlated with poorer survival of CRC patients. LncRNA XIST promoted CRC metastasis acting as a ceRNA for miR-125b-2-3p to mediate WEE1 expression. LncRNA XIST-miR-125b-2-3p-WEE1 axis not only regulated CRC growth and metastasis but also contributed to chemotherapeutic resistance to CRC.