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RNF115 aggravates tumor progression through regulation of CDK10 degradation in thyroid carcinoma.
Jinxiang Zhu
Longwei Guo
Hao Dai
Zhiwei Zheng
Jinfeng Yan
Junsong Liu
Shaoqiang Zhang
Xiang Li
Xin Sun
Qian Zhao
Chongwen Xu
Published in:
Cell biology and toxicology (2024)
RNF115 triggers cell proliferation, EMT, and tumor metastasis by ubiquitinating and degrading CDK10. The regulation of the Raf-1 pathway and cell cycle progression in THCA may be profoundly influenced by this process.
Keyphrases
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cell cycle
cell proliferation
epithelial mesenchymal transition
poor prognosis
dna damage response
pi k akt
signaling pathway
dna repair