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RNF115 aggravates tumor progression through regulation of CDK10 degradation in thyroid carcinoma.

Jinxiang ZhuLongwei GuoHao DaiZhiwei ZhengJinfeng YanJunsong LiuShaoqiang ZhangXiang LiXin SunQian ZhaoChongwen Xu
Published in: Cell biology and toxicology (2024)
RNF115 triggers cell proliferation, EMT, and tumor metastasis by ubiquitinating and degrading CDK10. The regulation of the Raf-1 pathway and cell cycle progression in THCA may be profoundly influenced by this process.
Keyphrases
  • cell cycle
  • cell proliferation
  • epithelial mesenchymal transition
  • poor prognosis
  • dna damage response
  • pi k akt
  • signaling pathway
  • dna repair