Three possible diagnostic biomarkers for gastric cancer: miR-362-3p, miR-362-5p and miR-363-5p.
Zahra Hassanpour AydinlouAli RajabiAli EmamiSamaneh Tayefeh-GholamiShahram TeimourianMirsaed Miri NargesiSeyed Mahdi Banan KhojastehReza SafaralizadehPublished in: Biomarkers in medicine (2024)
Aim: MicroRNAs can be regarded as biomarkers for gastric cancer (GC) diagnosis in the early stages. This study assesses the expression levels of miR-362-3p, miR-362-5p and miR-363-5p as potential biomarkers for GC. Materials & methods: The expression levels of the miRNAs in 90 pairs of GC and adjacent normal tissue samples were analyzed by quantitative real-time reverse transcription PCR (qRT-PCR) and some bioinformatics tools were utilized for analyzing the target genes and possible molecular pathways in which these miRNAs participate. Results & conclusion: There was a significant overexpression of the miRNAs in GC cells and an outstanding correlation between their overexpression with some clinicopathological features of the patients.
Keyphrases
- poor prognosis
- gas chromatography
- end stage renal disease
- transcription factor
- cell proliferation
- newly diagnosed
- ejection fraction
- induced apoptosis
- chronic kidney disease
- binding protein
- cell cycle arrest
- prognostic factors
- genome wide
- mass spectrometry
- long non coding rna
- cell death
- patient reported outcomes
- tandem mass spectrometry
- endoplasmic reticulum stress
- patient reported