p16 overexpression identifies oncogenic high-risk HPV infection in non-oropharyngeal squamous cell carcinoma of the head and neck.

Anne Sophie BeckerJenny MerkelInci BozkurtDaniel Fabian StrüderClaudia MaletzkiMaja HühnsAnnette Helene Zimpfer

Published in: Head & neck (2024)

We conclude that HPV-positive non-OPSCC are associated with p16 overexpression and low levels of pRb and cyclin D1. High expression of pRb and cyclin D1 indicates HPV-negativity.

Keyphrases

high grade
squamous cell carcinoma
cell cycle
cell proliferation
transcription factor
cervical cancer screening
poor prognosis
genome wide
cell cycle arrest
lymph node metastasis
cell death
dna methylation