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ESRRA modulation by empagliflozin mitigates diabetic tubular injury via mitochondrial restoration.

Keju YangWei LiangHongtu HuZongwei ZhangYiqun HaoZhixia SongLin YangJijia HuZhaowei ChenGuohua Ding
Published in: Cellular signalling (2024)
The diminished expression of ESRRA is implicated in the decline of mitochondrial mass in PTECs during the early stages of diabetes, highlighting it as a key target of EMPA for preventing the progression of diabetic kidney injury.
Keyphrases
  • type diabetes
  • oxidative stress
  • wound healing
  • poor prognosis
  • cardiovascular disease
  • glycemic control
  • radiation induced
  • radiation therapy
  • insulin resistance
  • high glucose
  • endothelial cells