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ESRRA modulation by empagliflozin mitigates diabetic tubular injury via mitochondrial restoration.
Keju Yang
Wei Liang
Hongtu Hu
Zongwei Zhang
Yiqun Hao
Zhixia Song
Lin Yang
Jijia Hu
Zhaowei Chen
Guohua Ding
Published in:
Cellular signalling (2024)
The diminished expression of ESRRA is implicated in the decline of mitochondrial mass in PTECs during the early stages of diabetes, highlighting it as a key target of EMPA for preventing the progression of diabetic kidney injury.
Keyphrases
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type diabetes
oxidative stress
wound healing
poor prognosis
cardiovascular disease
glycemic control
radiation induced
radiation therapy
insulin resistance
high glucose
endothelial cells