Hydroxychloroquine in the post-COVID-19 era: will this pandemic upset decades of clinical practice?
Lucie PothenHalil YildizMathilde Mbouck SamnickJean Cyr YombiPublished in: Clinical rheumatology (2021)
In the early stage of the COVID-19 pandemic, Belgian health authorities endorsed the interim guidelines for the treatment of COVID-19 pneumonia: hydroxychloroquine (HCQ) recommended for treatment of hospitalized patients with moderate to severe disease. As a growing number of patients were admitted, inevitably, our internal medicine team questioned the efficacy and safety of HCQ, especially with regard to cardiac side effects. In parallel with our concerns, data regarding the safety and efficacy of HCQ were published, with discordant results and debate in the medical community. Media coverage of the possible risks and benefits of HCQ use in COVID-19 also caused confusion amongst the public. In this Perspectives in Rheumatology article, we review the use and safety of HCQ in autoimmune disease and its putative efficacy and toxicity in COVID-19. Finally, we share our concern about the future of this widely used and inexpensive drug after the COVID-19 pandemic has passed.
Keyphrases
- coronavirus disease
- sars cov
- healthcare
- early stage
- clinical practice
- mental health
- end stage renal disease
- respiratory syndrome coronavirus
- public health
- multiple sclerosis
- oxidative stress
- peritoneal dialysis
- human health
- squamous cell carcinoma
- chronic kidney disease
- health information
- extracorporeal membrane oxygenation
- intensive care unit
- left ventricular
- current status
- radiation therapy
- drug induced
- electronic health record
- randomized controlled trial
- risk assessment
- respiratory failure
- locally advanced
- health promotion
- community acquired pneumonia