PI3K, p38 and JAK/STAT signalling in bronchial tissue from patients with asthma following allergen challenge.

Thomas SouthworthSarah MasonAlan BellIsabel RamisMarta CalbetAnna DomenechNeus PratsMontserrat MiralpeixDave Singh

Published in: Biomarker research (2018)

Future clinical trials of novel kinase inhibitors could use the allergen challenge model in proof of concept studies, while employing these biomarkers to investigate pharmacological inhibition in the lungs.

Keyphrases

allergic rhinitis
clinical trial
chronic obstructive pulmonary disease
lung function
randomized controlled trial
cystic fibrosis
study protocol