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Programmed cell death ligand 1 cut-point is associated with reduced disease specific survival in resected pancreatic ductal adenocarcinoma.

Basile Tessier-CloutierSteve E KallogerMohammad Al-KandariKaty MilneDongxia GaoBrad H NelsonDaniel J RenoufBrandon S SheffieldDavid F Schaeffer
Published in: BMC cancer (2017)
This data suggests that there is an inverse relationship between PD-L1 expression and disease specific survival times in resected PDAC. Consequently, this association may represent a phenotype where increased PD-L1 expression has an effect on tumor biology and could therefore identify a subgroup where PD1 blockade could have enhanced effectiveness.
Keyphrases
  • lymph node
  • randomized controlled trial
  • systematic review
  • free survival
  • electronic health record
  • prognostic factors
  • clinical trial
  • machine learning
  • artificial intelligence
  • data analysis