Programmed cell death ligand 1 cut-point is associated with reduced disease specific survival in resected pancreatic ductal adenocarcinoma.
Basile Tessier-CloutierSteve E KallogerMohammad Al-KandariKaty MilneDongxia GaoBrad H NelsonDaniel J RenoufBrandon S SheffieldDavid F SchaefferPublished in: BMC cancer (2017)
This data suggests that there is an inverse relationship between PD-L1 expression and disease specific survival times in resected PDAC. Consequently, this association may represent a phenotype where increased PD-L1 expression has an effect on tumor biology and could therefore identify a subgroup where PD1 blockade could have enhanced effectiveness.