Flow cytometry optimizing the diagnostic approach in inborn errors of immunity: experience from Egypt.

Safa S MeshaalRabab Ei HawaryAlia EldashAya ErfanDalia Abd ElazizRadwa AlkadySohilla LotfyNermeen GalalJeannette BoutrosAisha Elmarsafy

Published in: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology (2022)

Using multi-color FCM to evaluate immune cells populations, subpopulations, functions, and intracellular proteins expression is proved a useful cost-effective method for screening, categorization and follow up of IEI patients. FCM can improve the diagnosis of IEI significantly when tests are properly targeted and well designed. This study presents a 10-year experience in diagnosis of IEI using FCM at a tertiary referral center in a setting of limited resources and yet high prevalence of IEI.

Keyphrases

flow cytometry
end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
poor prognosis
primary care
prognostic factors
peritoneal dialysis