Childhood multiple sclerosis is associated with reduced brain volumes at first clinical presentation and brain growth failure.
Frederik BartelsKatharina NobisGraham CooperEva WendelRobert CleavelandBarbara Bajer-KornekAstrid BlaschekMareike SchimmelMarkus BlankenburgMatthias BaumannMichael KarenfortCarsten FinkeKevin RostásyPublished in: Multiple sclerosis (Houndmills, Basingstoke, England) (2019)
In pedMS patients, brain volume loss is present already at first clinical presentation and accelerated over 2 years. Increased disease activity is associated with more severe brain volume loss. MRI brain volume change might serve as an outcome parameter in future prospective pedMS studies.
Keyphrases
- white matter
- resting state
- multiple sclerosis
- disease activity
- functional connectivity
- rheumatoid arthritis
- cerebral ischemia
- magnetic resonance imaging
- end stage renal disease
- rheumatoid arthritis patients
- peritoneal dialysis
- ankylosing spondylitis
- young adults
- magnetic resonance
- early onset
- prognostic factors
- blood brain barrier
- brain injury
- current status