Long non-coding RNA NORAD/miR-224-3p/MTDH axis contributes to CDDP resistance of esophageal squamous cell carcinoma by promoting nuclear accumulation of β-catenin.

Yunlong JiaCong TianHongyan WangFan YuWei LvYuqing DuanZishuo ChengXuexiao WangYu WangTianxu LiuJiali WangYunlong Jia

Published in: Molecular cancer (2021)

NORAD upregulates MTDH to promote CDDP resistance and progression in ESCC by sponging miR-224-3p. Our results highlight the potential of NORAD as a therapeutic target in ESCC patients receiving CDDP-based chemotherapy.

Keyphrases

long non coding rna
poor prognosis
epithelial mesenchymal transition
cell proliferation
locally advanced
squamous cell carcinoma
risk assessment
climate change
chemotherapy induced