Autoantibodies Targeting Nephrin in Podocytopathies.
Felicitas E HengelSilke DehdeMoritz LasséGunther ZahnerLarissa SeifertAnnabel SchnarreOliver KretzFatih DemirHans O PinnschmidtFlorian GrahammerRenke LucasLea Maxima MehnerTom ZimmermannAnja M BillingJun OhAdele MitrottiPaola PontrelliHanna DebiecClaire DossierManuela ColucciFrancesco EmmaWilliam E SmoyerAstrid WeinsFranz SchaeferNada AlachkarAnke DiemertJulien HoganElion HoxhaThorsten WiechMarkus M RinschenPierre RoncoMarina VivarelliLoreto GesualdoNicola M TomasTobias B Hubernull nullPublished in: The New England journal of medicine (2024)
In this study, circulating antinephrin autoantibodies were common in patients with minimal change disease or idiopathic nephrotic syndrome and appeared to be markers of disease activity. Their binding at the slit diaphragm induced podocyte dysfunction and nephrotic syndrome, which highlights their pathophysiological significance. (Funded by Deutsche Forschungsgemeinschaft and others.).