Integrative analysis of vascular endothelial cell genomic features identifies AIDA as a coronary artery disease candidate gene.
Simon LalondeValérie-Anne Codina-FauteuxSébastian Méric de BellefonFrancis LeblancMélissa BeaudoinMarie-Michelle SimonRola DaliTony KwanKen Sin LoTomi PastinenGuillaume LettrePublished in: Genome biology (2019)
Our data support an important role played by genetic variants acting in the vascular endothelium to modulate inter-individual risk in CAD and hypertension.
Keyphrases
- coronary artery disease
- genome wide
- copy number
- endothelial cells
- blood pressure
- percutaneous coronary intervention
- cardiovascular events
- nitric oxide
- coronary artery bypass grafting
- electronic health record
- big data
- heart failure
- type diabetes
- cardiovascular disease
- network analysis
- data analysis
- atrial fibrillation