Weighted Gene Co-Expression Network Analysis Reveals Dysregulation of Mitochondrial Oxidative Phosphorylation in Eating Disorders.
Liulin YangYun LiTurki TurkiHuizi TanZhi WeiXiao ChangPublished in: Genes (2018)
The underlying mechanisms of eating disorders (EDs) are very complicated and still poorly understood. The pathogenesis of EDs may involve the interplay of multiple genes. To investigate the dysregulated gene pathways in EDs we analyzed gene expression profiling in dorsolateral prefrontal cortex (DLPFC) tissues from 15 EDs cases, including 3 with anorexia nervosa (AN), 7 with bulimia nervosa (BN), 2 AN-BN cases, 3 cases of EDs not otherwise specified, and 102 controls. We further used a weighted gene co-expression network analysis to construct a gene co-expression network and to detect functional modules of highly correlated genes. The functional enrichment analysis of genes in co-expression modules indicated that an altered mitochondrial oxidative phosphorylation process may be involved in the pathogenesis of EDs.
Keyphrases
- network analysis
- genome wide identification
- genome wide
- poor prognosis
- anorexia nervosa
- copy number
- prefrontal cortex
- genome wide analysis
- dna methylation
- transcription factor
- oxidative stress
- binding protein
- gene expression
- magnetic resonance
- long non coding rna
- computed tomography
- working memory
- transcranial magnetic stimulation