Generation of a thrombopoietin-deficient thrombocytopenia model in zebrafish.

Lian Yang Liangliang Wu Panpan Meng Xuebing Zhang Dejian Zhao Qing Lin Wenqing Zhang

Published in: Journal of thrombosis and haemostasis : JTH (2022)

presented with a significant reduction of thpo expression and developed thrombocytopenia. Thpo loss-of-function zebrafish model can serve as a valuable preclinical model for thrombocytopenia caused by thpo-deficiency, as well as a tool to study human clinical THPO variants and evaluate the effect of THPO-RAs.

Keyphrases

endothelial cells
poor prognosis
gene expression
copy number
mesenchymal stem cells
long non coding rna
wild type