Epigenetic Silencing of miRNA-338-5p and miRNA-421 Drives SPINK1-Positive Prostate Cancer.

Vipul BhatiaAnjali YadavRitika TiwariShivansh NigamSakshi GoelShannon CarskadonNilesh GuptaNallasivam Palanisamy Bushra Ateeq

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2018)

Our findings revealed that miRNA-338-5p/-421 are epigenetically silenced in SPINK1-positive prostate cancer, although restoring the expression of these miRNAs using epigenetic drugs or synthetic mimics could abrogate SPINK1-mediated oncogenesis.See related commentary by Bjartell, p. 2679.

Keyphrases

prostate cancer
radical prostatectomy
dna methylation
gene expression
poor prognosis
drug induced
long non coding rna