The effects of icariin on wound healing of extraction sites with administration of zoledronic and dexamethasone: A rat model study.

Jie LiuNikos MattheosCheng SuChuanxi DengNanyu LuoZekun WangHua Tang

Published in: Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology (2017)

Concurrent use of zoledronic and dexamethasone inhibits the expression of VEGF, OCN, and wound healing and increases the number of osteoclast cells, serum CTX-1, and TRACP-5b after discontinuation for 10 weeks. Icariin weakens those effects in a dose-dependent manner but does not influence the onset of BRONJ.

Keyphrases

wound healing
induced apoptosis
high dose
low dose
poor prognosis
cell cycle arrest
endothelial cells
vascular endothelial growth factor
squamous cell carcinoma
oxidative stress
escherichia coli
klebsiella pneumoniae
long non coding rna
bone loss