Cytokeratin profile and keratinocyte gene expression in keratinized lid margins of patients with chronic Stevens-Johnson syndrome.

Madhuri Amulya KoduriJilu JaffetSwapna S ShanbhagSayan BasuVivek SinghSwati Singh

Published in: Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (2022)

In lid margins of SJS, there is an increased expression of keratinization-related genes compared to the normal lid margin. Keratinized LMC shares similar cytokeratin profile and keratinization gene expression as seen in cutaneous epithelium of SJS patients, indicating the possibility of the cutaneous epithelium as a source for keratinized LMC.

Keyphrases

gene expression
end stage renal disease
dna methylation
newly diagnosed
ejection fraction
poor prognosis
chronic kidney disease
prognostic factors
peritoneal dialysis
patient reported outcomes
long non coding rna
binding protein