Repurposing N-acetylcysteine for management of non-acetaminophen induced acute liver failure: an evidence scan from a global health perspective.
Rebecca N JeromeLaura A ZahnJessica J AbnerMeghan M JolyJana K Shirey-RiceRobert S WallisGordon R BernardJill M PulleyPublished in: Translational gastroenterology and hepatology (2024)
This body of literature indicates efficacy and safety of NAC in non-acetaminophen induced ALF. Given the presence of NAC on the EML, this medication is likely to be available across a range of resource settings; promulgating its use in this novel subset of ALF can provide healthcare professionals and patients with a valuable and safe complement to supportive care for this disease.
Keyphrases
- global health
- liver failure
- transcription factor
- liver injury
- drug induced
- healthcare
- public health
- hepatitis b virus
- high glucose
- systematic review
- diabetic rats
- palliative care
- computed tomography
- genome wide analysis
- quality improvement
- adverse drug
- magnetic resonance imaging
- oxidative stress
- endothelial cells
- magnetic resonance
- electronic health record
- stress induced
- drug discovery