ANXA1sp modulates the protective effect of Sirt3-induced mitophagy against sepsis-induced myocardial injury in mice.

Wanyu MaZhijia HuangYanmei MiaoXinglong MaZhiquan ZhangWenjie LiuPeng Xie

Published in: Acta physiologica (Oxford, England) (2024)

ANXA1sp can reverse SIMI, and the underlying mechanism may be related to the activation of the AMPK-mTOR pathway following upregulation of Sirt3 by ANXA1sp, which, in turn, induces autophagy.

Keyphrases

oxidative stress
diabetic rats
high glucose
cell proliferation
drug induced
signaling pathway
intensive care unit
ischemia reperfusion injury
acute kidney injury
type diabetes
endothelial cells
poor prognosis
endoplasmic reticulum stress
adipose tissue
metabolic syndrome
living cells
high fat diet induced