Metabolic Communication by SGLT2 Inhibition.
Anja M BillingYoung Chul KimSøren GullaksenBenedikt SchrageJanice RaabeArvid D HutzfeldtFatih DemirElina KovalenkoMoritz LasséAurelien DugourdRobin FalleggerBirgit KlampeJohannes JaegersQing LiOlha KravtsovaMaria Crespo-MasipAmelia PalermoRobert A FentonElion HoxhaStefan BlankenbergPaulus F KirchhofTobias B HuberEsben LaugesenTanja ZellerMaria ChrysopoulouJulio Saez-RodriguezChristina MagnussenThomas EschenhagenAlexander StaruschenkoGary E SiuzdakPer L PoulsenClarissa SchwabFriederike CuelloVolker VallonMarkus M RinschenPublished in: Circulation (2023)
SGLT2i reduced microbiome formation of uremic toxins such as p-cresol sulfate and thereby their body exposure and need for renal detoxification, which, combined with direct kidney effects of SGLT2i, including less proximal tubule glucotoxicity and a broad downregulation of apical transporters (including sodium, amino acid, and urate uptake), provides a metabolic foundation for kidney and cardiovascular protection.