PATHOPHYSIOLOGY OF POSTTRAUMATIC ANKLE OSTEOARTHRITIS: A MULTICENTER PERSPECTIVE.
Alexandre Leme GodoyCesar De Cesar NettoSimone SantiniMario Herrera PerezVictor ValderrabanoStefan RammeltPublished in: Acta ortopedica brasileira (2024)
The pathophysiological factors involved in posttraumatic ankle osteoarthritis, such as biological, structural, mechanical, and molecular changes must be studied together, as the interaction between these factors determines the risk of progression of PTOA. Inhibition of a single catabolic molecule or cascade probably is not sufficient to alter the natural progression of the pathological process.