Phylogenomic analyses of multidrug resistant Corynebacterium striatum strains isolated from patients in a tertiary care hospital in the UK.
Vartul SangalEmma C L MarrsAndrew NelsonJohn D PerryPublished in: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology (2024)
Corynebacterium striatum is an emerging nosocomial pathogen. This is the first report showing the presence of three distinct multidrug resistant lineages of C. striatum among patients in a UK hospital. The presence of ErmX, Tet(W), Bla and AmpC proteins, and mutations in gyrA gene are associated with the resistance to clindamycin, doxycycline, penicillin and moxifloxacin, respectively. These strains are equipped with several corynebacterial virulence genes including two SpaDEF-type and a novel pilus gene cluster, which needs further molecular characterisation. This study highlights a need of developing an active surveillance strategy for routine monitoring and preventing potential cross-transmission among susceptible patients.
Keyphrases
- multidrug resistant
- end stage renal disease
- escherichia coli
- ejection fraction
- newly diagnosed
- chronic kidney disease
- peritoneal dialysis
- healthcare
- prognostic factors
- acinetobacter baumannii
- genome wide
- drug resistant
- copy number
- cross sectional
- transcription factor
- patient reported outcomes
- climate change
- methicillin resistant staphylococcus aureus
- candida albicans
- genome wide analysis
- single molecule
- bioinformatics analysis