Stroma AReactive Invasion Front Areas (SARIFA) proves prognostic relevance in gastric carcinoma and is based on a tumor-adipocyte interaction indicating an altered immune response.

Bianca GrosserChristian M HeyerJohannes AustgenEva SiposNic G ReitsamAndreas HauserAlison VanSchoiackDavid KroepplerDmytro VlasenkoAndreas ProbstAlexander NovotnyWilko WeichertGisela KellerMatthias SchlesnerBruno Märkl

Published in: Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association (2023)

SARIFA proves to be a strong negative prognostic biomarker in advanced gastric cancer, implicating an interaction of tumor cells with tumor-promoting adipocytes with crucial changes in tumor cell metabolism. SARIFA is not driven by tumor genetics but is very likely driven by an altered immune response as a causative mechanism.

Keyphrases

immune response
adipose tissue
dendritic cells
stem cells
type diabetes
single cell
toll like receptor
metabolic syndrome
lymph node
mesenchymal stem cells
fatty acid