The role of environmental stress and DNA methylation in the longitudinal course of bipolar disorder.
Ashley L ComesDarina CzamaraKristina AdorjanHeike Anderson-SchmidtTill F M AndlauerMonika BuddeKatrin GadeMaria HakeJanos L KalmanSergi PapiolDaniela Reich-ErkelenzFarah Klöhn-SaghatolislamSabrina K SchauppEva C SchulteFanny SennerGeorg JuckelMax SchmaußJörg ZimmermannJens ReimerEva ReininghausIon-George AnghelescuCarsten KonradAndreas ThielChristian FiggeMartin von HagenManfred KollerDetlef E DietrichSebastian StierlHarald ScherkStephanie H WittSugirthan SivalingamFranziska DegenhardtAndreas J ForstnerMarcella RietschelMarkus M NöthenJens WiltfangPeter FalkaiThomas G SchulzeUrs HeilbronnerPublished in: International journal of bipolar disorders (2020)
To the best of our knowledge, our study is the first to investigate epigenome-wide methylation across time in bipolar patients and in relation to recent, non-traumatic stressful life events. Limited and inconclusive evidence warrants future longitudinal investigations in larger samples of well-characterized bipolar patients to give a complete picture regarding the role of DNA methylation in the course of bipolar disorder.