Machine Learning Based Prediction of Gamma Passing Rate for VMAT Radiotherapy Plans.

The use of machine learning algorithms (ML) in radiotherapy is becoming increasingly popular. More and more groups are trying to apply ML in predicting the so-called gamma passing rate (GPR). Our team has developed a customized approach of using ML algorithms to predict global GPR for electronic portal imaging device (EPID) verification for dose different 2% and distance to agreement 2 mm criteria for VMAT dynamic plans. Plans will pass if the GPR is greater than 98%. The algorithm was learned and tested on anonymized clinical data from 13 months which resulted in more than 3000 treatment plans. The obtained results of GPR prediction are very interesting. Average specificity of the algorithm based on an ensemble of 50 decision tree regressors is 91.6% for our criteria. As a result, we can reduce the verification process by 50%. The novel approach described by our team can offer a new insight into the application of ML and neural networks in GPR prediction and dosimetry.