Sex-dependent effects of endocannabinoid modulation of conditioned fear extinction in rats.

Maria Morena Andrei S NastaseAlessia SantoriBenjamin F CravattRebecca M ShanskyMatthew N Hill

Published in: British journal of pharmacology (2021)

We provide the first evidence that AEA and 2-AG signalling affect fear expression and extinction in females in opposite directions. These findings are relevant to future research on sex differences in mechanisms of fear extinction and may help develop sex-specific therapeutics to treat trauma-related disorders.

Keyphrases

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