miR-20b, miR-296, and Let-7f Expression in Human Adipose Tissue is Related to Obesity and Type 2 Diabetes.
Adriana-Mariel GentileSaid LhamyaniLeticia Coín-AragüezMercedes Clemente-PostigoWilfredo Oliva OliveraSilvana-Yanina Romero-ZerboSara García-SerranoEva García-EscobarHatem ZayedEsther DobladoFrancisco-Javier Bermúdez-SilvaMora MurriFrancisco J TinahonesRajaa El BekayPublished in: Obesity (Silver Spring, Md.) (2018)
This study provides experimental evidence of the possible correlation between AT miR-20b-miR-296-Let-7f with obesity and T2D, which might involve vascular endothelial growth factor and WNT-dependent pathways that are regulated by six different genes, suggesting a novel signaling pathway that could be important for understanding the mechanisms underlying the AT dysfunction associated with obesity and T2D.
Keyphrases
- insulin resistance
- type diabetes
- vascular endothelial growth factor
- adipose tissue
- cell proliferation
- metabolic syndrome
- weight loss
- high fat diet induced
- long non coding rna
- endothelial cells
- signaling pathway
- weight gain
- poor prognosis
- high fat diet
- long noncoding rna
- skeletal muscle
- stem cells
- glycemic control
- cardiovascular disease
- body mass index
- genome wide
- dna methylation
- oxidative stress
- gene expression
- physical activity
- induced apoptosis
- bioinformatics analysis