GADD45A regulates subcutaneous fat deposition and lipid metabolism by interacting with Stat1.
Wenjing YouShiqi LiuJie LiYuang TuTizhong ShanPublished in: BMC biology (2023)
Overall, our results reveal the critical regulatory roles of GADD45A in subcutaneous fat deposition and lipid metabolism. We demonstrate that GADD45A deficiency induces the inguinal white adipose tissue (iWAT) browning and protects mice against HFD-induced obesity. Our findings provide new potential targets for combating obesity-related metabolic diseases and improving human health.
Keyphrases
- high fat diet induced
- adipose tissue
- insulin resistance
- human health
- high fat diet
- risk assessment
- fatty acid
- climate change
- metabolic syndrome
- weight loss
- type diabetes
- high glucose
- diabetic rats
- skeletal muscle
- weight gain
- drug induced
- cell proliferation
- transcription factor
- genome wide
- oxidative stress
- smoking cessation
- physical activity