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SETDB1 Restrains Endogenous Retrovirus Expression and Antitumor Immunity during Radiotherapy.

Dong PanXuhui BaoMengjie HuMeng JiaoFang LiChuan-Yuan Li
Published in: Cancer research (2022)
The identification of the SETDB1-mediated suppression of radiotherapy-induced viral mimicry reveals SETDB1 inhibition as a potential approach to sensitize tumors to radiotherapy by enhancing the type I interferon response.
Keyphrases
  • early stage
  • locally advanced
  • radiation therapy
  • radiation induced
  • poor prognosis
  • sars cov
  • squamous cell carcinoma
  • dendritic cells
  • diabetic rats
  • immune response
  • risk assessment
  • long non coding rna
  • climate change