Identifying chemogenetic interactions from CRISPR screens with drugZ.

Medina ColicGang WangMichal ZimmermannKeith MascallMegan McLaughlinLori BertoletW Frank LenoirJason MoffatStephane AngersDaniel DurocherTraver Hart

Published in: Genome medicine (2019)

DrugZ is an open-source Python software for the analysis of genome-scale drug modifier screens. The software accurately identifies genetic perturbations that enhance or suppress drug activity. Interestingly, analysis of new and previously published data reveals tumor suppressor genes are drug-agnostic resistance genes in drug modifier screens. The software is available at github.com/hart-lab/drugz .

Keyphrases

genome wide
dna methylation
copy number
high throughput
adverse drug
data analysis
drug induced
gene expression
machine learning
systematic review
big data
single cell
genome wide analysis