Association of childhood infections and perinatal factors with ankylosing spondylitis: a Swedish nationwide case-control and sibling study.
Matilda MorinKarin HellgrenUlf LindströmThomas FrisellPublished in: RMD open (2023)
Having older siblings and a history of tonsillectomy in childhood were independently associated with development of AS, even after adjustment for family-shared factors in a sibling comparison analysis. This strengthens the hypothesis that childhood infections play a role in the aetiology of AS.