Clinical presentation of new onset refractory status epilepticus in children (the pSERG cohort).
Claudine SculierCristina Barcia AguilarNicolas GaspardMarina Gaínza-LeinIván Sánchez FernándezMarta Amengual-GualAnne AndersonRavindra AryaBrian T BurrowsJames N BrentonJessica L CarpenterKevin E ChapmanJustice ClarkWilliam Davis GaillardTracy A GlauserJoshua L GoldsteinHoward P GoodkinMark GormanYi-Chen LaiTiffani L McDonoughMohamad A MikatiAnuranjita NayakKatrina PearisoJames RivielloAllison RusieKatherine SperbergCoral M StrednyRobert C TaskerDmitry TchapyjnikovAlejandra VasquezMark S WainwrightAngus A WilfongKorwyn WilliamsTobias Loddenkempernull nullPublished in: Epilepsia (2021)
Among pediatric patients with RSE, 16% met diagnostic criteria for NORSE, including the subcategory of febrile infection-related epilepsy syndrome (FIRES). Pediatric NORSE cases may also overlap with refractory febrile SE (FSE). FIRES occurs more frequently in older children, the course is usually prolonged, and outcomes are worse, as compared to refractory FSE. Fever occurring more than 24 h before the onset of seizures differentiates a subgroup of NORSE patients with distinctive clinical characteristics and worse outcomes.