Adipose Stromal/Stem Cell-Derived Extracellular Vesicles: Potential Next-Generation Anti-Obesity Agents.
Mariachiara ZuccariniPatricia GiulianiValentina Di LibertoMonica FrinchiFrancesco CaciagliVanni CarusoRenata CiccarelliGiuseppa MudòPatrizia Di IorioPublished in: International journal of molecular sciences (2022)
Over the last decade, several compounds have been identified for the treatment of obesity. However, due to the complexity of the disease, many pharmacological interventions have raised concerns about their efficacy and safety. Therefore, it is important to discover new factors involved in the induction/progression of obesity. Adipose stromal/stem cells (ASCs), which are mostly isolated from subcutaneous adipose tissue, are the primary cells contributing to the expansion of fat mass. Like other cells, ASCs release nanoparticles known as extracellular vesicles (EVs), which are being actively studied for their potential applications in a variety of diseases. Here, we focused on the importance of the con-tribution of ASC-derived EVs in the regulation of metabolic processes. In addition, we outlined the advantages/disadvantages of the use of EVs as potential next-generation anti-obesity agents.
Keyphrases
- insulin resistance
- adipose tissue
- stem cells
- metabolic syndrome
- weight loss
- high fat diet induced
- induced apoptosis
- type diabetes
- weight gain
- high fat diet
- skeletal muscle
- cell cycle arrest
- bone marrow
- oxidative stress
- physical activity
- human health
- endoplasmic reticulum stress
- mesenchymal stem cells
- cell death
- cell therapy
- cell proliferation
- body mass index
- fatty acid
- risk assessment
- pi k akt
- replacement therapy