1α,25-dihydroxyvitamin D3 protects retinal ganglion cells in glaucomatous mice.
Francesca LazzaraRosario AmatoChiara Bianca Maria PlataniaFederica ContiTsung-Han ChouVittorio PorciattiFilippo DragoClaudio BucoloPublished in: Journal of neuroinflammation (2021)
1,25(OH)2D3 protected RGCs preserving retinal function, reducing inflammatory cytokines, and increasing expression of neuroprotective factors. Therefore, 1,25(OH)2D3 could attenuate the retinal damage in glaucomatous patients and warrants further clinical evaluation for the treatment of optic neuropathies.
Keyphrases
- optic nerve
- optical coherence tomography
- clinical evaluation
- end stage renal disease
- diabetic retinopathy
- induced apoptosis
- newly diagnosed
- ejection fraction
- chronic kidney disease
- poor prognosis
- oxidative stress
- peritoneal dialysis
- type diabetes
- cell cycle arrest
- patient reported outcomes
- cell death
- blood brain barrier
- long non coding rna
- endoplasmic reticulum stress
- insulin resistance
- replacement therapy
- patient reported