ChAdOx1 nCoV-19 (AZD1222) protects Syrian hamsters against SARS-CoV-2 B.1.351 and B.1.1.7.
Robert J FischerNeeltje Van DoremalenDanielle R AdneyClaude Kwe YindaJulia R PortMyndi G HolbrookJonathan E SchulzBrandi N WilliamsonTina ThomasKent BarbianSarah L AnzickStacy RicklefsBrian J SmithDan LongCraig MartensGreg SaturdayEmmie de WitSarah C GilbertTeresa LambeVincent J MunsterPublished in: Nature communications (2021)
We investigated ChAdOx1 nCoV-19 (AZD1222) vaccine efficacy against SARS-CoV-2 variants of concern (VOCs) B.1.1.7 and B.1.351 in Syrian hamsters. We previously showed protection against SARS-CoV-2 disease and pneumonia in hamsters vaccinated with a single dose of ChAdOx1 nCoV-19. Here, we observe a 9.5-fold reduction of virus neutralizing antibody titer in vaccinated hamster sera against B.1.351 compared to B.1.1.7. Vaccinated hamsters challenged with B.1.1.7 or B.1.351 do not lose weight compared to control animals. In contrast to control animals, the lungs of vaccinated animals do not show any gross lesions. Minimal to no viral subgenomic RNA (sgRNA) and no infectious virus can be detected in lungs of vaccinated animals. Histopathological evaluation shows extensive pulmonary pathology caused by B.1.1.7 or B.1.351 replication in the control animals, but none in the vaccinated animals. These data demonstrate the effectiveness of the ChAdOx1 nCoV-19 vaccine against clinical disease caused by B.1.1.7 or B.1.351 VOCs.
Keyphrases
- sars cov
- respiratory syndrome coronavirus
- randomized controlled trial
- systematic review
- pulmonary hypertension
- physical activity
- magnetic resonance
- body mass index
- weight loss
- computed tomography
- high resolution
- coronavirus disease
- gene expression
- machine learning
- copy number
- genome wide
- acute respiratory distress syndrome
- big data
- deep learning
- zika virus
- high speed
- respiratory failure