The Results of the URRAH (Uric Acid Right for Heart Health) Project: A Focus on Hyperuricemia in Relation to Cardiovascular and Kidney Disease and its Role in Metabolic Dysregulation.
Alessandro MalobertiAlessandro MengozziElisa RussoArrigo Francesco Giuseppe CiceroFabio AngeliEnrico Agabiti RoseiCarlo Maria BarbagalloBruno BernardinoMichele BombelliFederica CappelliEdoardo CasigliaRosario CianciMichele CiccarelliMassimo CirilloPietro CirilloGiovambattista DesideriLanfranco D'EliaRaffaella Dell'OroRita FacchettiClaudio FerriFerruccio GallettiCristina GiannattasioLoreto GesualdoGuido IaccarinoLuciano LippaFrancesca MallamaciStefano MasiMaria MasulliAlberto MazzaMaria Lorenza MuiesanPietro NazzaroGianfranco ParatiPaolo PalatiniPaolo PaulettoRoberto PontremoliNicola Riccardo PuglieseFosca Quarti-TrevanoMarcello RattazziGianpaolo ReboldiGiulia RivasiMassimo SalvettiValerie TikhonoffGiuliano TocciAndrea UngarPaolo VerdecchiaFrancesca ViazziMassimo VolpeAgostino VirdisGuido GrassiClaudio Borghinull nullPublished in: High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension (2023)
The relationship between Serum Uric Acid (UA) and Cardiovascular (CV) diseases has already been extensively evaluated, and it was found to be an independent predictor of all-cause and cardiovascular mortality but also acute coronary syndrome, stroke and heart failure. Similarly, also many papers have been published on the association between UA and kidney function, while less is known on the role of UA in metabolic derangement and, particularly, in metabolic syndrome. Despite the substantial number of publications on the topic, there are still some elements of doubt: (1) the better cut-off to be used to refine CV risk (also called CV cut-off); (2) the needing for a correction of UA values for kidney function; and (3) the better definition of its role in metabolic syndrome: is UA simply a marker, a bystander or a key pathological element of metabolic dysregulation?. The Uric acid Right for heArt Health (URRAH) project was designed by the Working Group on uric acid and CV risk of the Italian Society of Hypertension to answer the first question. After the first papers that individuates specific cut-off for different CV disease, subsequent articles have been published responding to the other relevant questions. This review will summarise most of the results obtained so far from the URRAH research project.
Keyphrases
- uric acid
- metabolic syndrome
- heart failure
- quality improvement
- acute coronary syndrome
- atrial fibrillation
- public health
- healthcare
- mental health
- insulin resistance
- blood pressure
- health information
- risk assessment
- type diabetes
- systematic review
- cardiovascular events
- cardiovascular disease
- randomized controlled trial
- health promotion
- percutaneous coronary intervention
- human health
- antiplatelet therapy
- climate change
- cerebral ischemia
- subarachnoid hemorrhage