The Effect of Exogenous Superoxide Dismutase (SOD) on Caspase-3 Activation and Apoptosis Induction in Pc-3 Prostate Cancer Cells.

Jufriady IsmySuwandi SugandiDedi RachmadiSunaryo HardjowijotoAkhmad Mustafa

Published in: Research and reports in urology (2020)

Administration of superoxide dismutase (SOD) increased apoptosis in a prostate cancer cell line (PC-3) through the increased expression of caspase-3. Superoxide dismutase (SOD) can be considered as a therapy for late-stage prostate cancer that had been progressed to hormone resistant and metastasized and promote apoptosis in those prostate cancer cells.

Keyphrases

prostate cancer
cell death
cell cycle arrest
endoplasmic reticulum stress
oxidative stress
induced apoptosis
radical prostatectomy
hydrogen peroxide
amyotrophic lateral sclerosis
poor prognosis
pi k akt
long non coding rna
signaling pathway