NiH-catalyzed dearomative hydroalkylation of indoles.

Kai LiuYu-Feng SongYang GaoJie-Qiong LuoYi-Xia Jia

Published in: Chemical communications (Cambridge, England) (2022)

A NiH-catalyzed intermolecular dearomative hydroalkylation of indoles has been developed, which assembles an array of structurally diverse C2-alkylated indolines with moderate to excellent yields. This protocol exhibits good functional group tolerance, allowing for late-stage functionalization of complex drug molecules.

Keyphrases

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