A long-term anti-inflammation markedly alleviated high-fat diet-induced obesity by repeated administrations of overexpressing IL10 human umbilical cord-derived mesenchymal stromal cells.
Liudi WangTianyun GaoYu LiYuanyuan XieSheng ZengChenxu TaiYirui FengPingping ShenBin WangPublished in: Stem cell research & therapy (2022)
A lasting anti-inflammation based on gene modified stem cell therapy is an effective strategy in preventing diet-induced obesity and obesity-related metabolic syndrome.
Keyphrases
- high fat diet induced
- insulin resistance
- metabolic syndrome
- cell therapy
- umbilical cord
- mesenchymal stem cells
- weight loss
- oxidative stress
- adipose tissue
- type diabetes
- weight gain
- endothelial cells
- skeletal muscle
- uric acid
- stem cells
- bone marrow
- cardiovascular disease
- body mass index
- physical activity
- pluripotent stem cells
- induced pluripotent stem cells
- dna methylation
- transcription factor