Association between Acute Declines in Estimated Glomerular Filtration Rate during Renin-Angiotensin System Inhibition and Risk of Adverse Outcomes.
Elaine KuHocine TighiouartCharles E McCullochLesley A InkerOgechi AdingwupuTom GreeneRaymond O EstacioMark WoodwardDick de ZeeuwJulia B LewisThierry HannedoucheFan Fan HouTazeen Hasan JafarEnyu ImaGuiseppe RemuzziHiddo J Lambers HeerspinkRobert D TotoMark J SarnakPublished in: Journal of the American Society of Nephrology : JASN (2024)
In people treated with RAS inhibitors, ≤ 13% decline in eGFR over a 3-month period or ≤21% decline over a 1-month period was associated with lower risk of kidney failure compared with no decline with the use of placebo or other agents.