The effectiveness and safety of oral medications, onabotulinumtoxinA (Three doses) and transcutaneous tibial nerve stimulation (TTNS) as non or minimally invasive treatment for the management of neurogenic detrusor overactivity (NDO) in adults: A systematic review and network meta-analysis.

OnabotulinumtoxinA injection is probably the most effective way to treat patients with NDO, with increasing effectiveness but decreasing safety as the dose rises. The effectiveness of α-blockers and TTNS was not statistically different from the placebo group. Antimuscarinics and β3-adrenoceptor-agonists have good effectiveness and safety.