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Rh(III)-Catalyzed Diastereodivergent Spiroannulation of Cyclic Imines with Activated Alkenes.

Bingxian LiuPanjie HuYing ZhangYunyun LiDachang BaiXingwei Li
Published in: Organic letters (2017)
Rh(III)-catalyzed [3 + 2] annulation of cyclic N-sulfonyl or N-acyl ketimines with activated alkenes has been realized, leading to the synthesis of spirocycles with three continuous stereogenic centers. This atom-economic reaction proceeded efficiently under mild and redox-neutral conditions via a C-H activation pathway, and the coupling is diastereodivergent, with the diastereoselectivity being controlled by silver additives.
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