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Application of CRISPR/Cas9 Technology in Cancer Treatment: A Future Direction.

Ali A RabaanHajir A Al SaihatiRehab BukhamsinMuhammed A BakhrebahMajed S NassarAbdulmonem A AlsalehYousef N AlhashemAmmar Y BukhamseenKhalil Al-RuhimyMohammed AlotaibiRoua A AlsubkiHejji E AlahmedSaleh Al-AbdulhadiFatemah A AlhashemAhlam A AlqatariAhmed AlsayyahRamadan Abdelmoez FarahatRwaa H AbdulalAli H Al-AhmedMohd ImranRanjan K Mohapatra
Published in: Current oncology (Toronto, Ont.) (2023)
Gene editing, especially with clustered regularly interspaced short palindromic repeats associated protein 9 (CRISPR-Cas9), has advanced gene function science. Gene editing's rapid advancement has increased its medical/clinical value. Due to its great specificity and efficiency, CRISPR/Cas9 can accurately and swiftly screen the whole genome. This simplifies disease-specific gene therapy. To study tumor origins, development, and metastasis, CRISPR/Cas9 can change genomes. In recent years, tumor treatment research has increasingly employed this method. CRISPR/Cas9 can treat cancer by removing genes or correcting mutations. Numerous preliminary tumor treatment studies have been conducted in relevant fields. CRISPR/Cas9 may treat gene-level tumors. CRISPR/Cas9-based personalized and targeted medicines may shape tumor treatment. This review examines CRISPR/Cas9 for tumor therapy research, which will be helpful in providing references for future studies on the pathogenesis of malignancy and its treatment.
Keyphrases
  • crispr cas
  • genome editing
  • gene therapy
  • public health
  • stem cells
  • dna methylation
  • high throughput
  • gene expression
  • mesenchymal stem cells
  • drug delivery
  • cell therapy
  • replacement therapy
  • sensitive detection