A Three-Component Derivatization Protocol for Determining the Enantiopurity of Sulfinamides by 1H and 19F NMR Spectroscopy.
Robin R GroleauRobert S L ChapmanHarry Ley-SmithLiyuan LiuTony David JamesSteven D BullPublished in: The Journal of organic chemistry (2019)
A practically simple three-component chiral derivatization protocol has been developed to determine the enantiopurity of eight S-chiral sulfinamides by 1H and 19F NMR spectroscopic analysis, based on their treatment with a 2-formylphenylboronic acid template and enantiopure pinanediol to afford a mixture of diastereomeric sulfiniminoboronate esters whose diastereomeric ratio is an accurate reflection of the enantiopurity of the parent sulfinamide.
Keyphrases
- ms ms
- liquid chromatography tandem mass spectrometry
- randomized controlled trial
- high performance liquid chromatography
- gas chromatography mass spectrometry
- high resolution
- simultaneous determination
- liquid chromatography
- tandem mass spectrometry
- gas chromatography
- magnetic resonance
- capillary electrophoresis
- ionic liquid
- molecular docking
- solid phase extraction
- mass spectrometry
- ultra high performance liquid chromatography
- molecularly imprinted
- combination therapy
- solid state
- high resolution mass spectrometry
- replacement therapy