Efficient two-step multivariate random effects meta-analysis of individual participant data for longitudinal clinical trials using mixed effects models.

Hisashi NomaKazushi MaruoMasahiko GoshoStephen Z LevineYair GoldbergStefan LeuchtToshi A Furukawa

Published in: BMC medical research methodology (2019)

The two-step approach is an effective method for IPD meta-analyses of longitudinal clinical trials using mixed effects models. It can also effectively circumvent the modellings of the between-studies heterogeneity of the variance-covariance parameters, and enable efficient inferences for the regression coefficient parameters.

Keyphrases

clinical trial
systematic review
meta analyses
cross sectional
magnetic resonance imaging
machine learning
big data
phase ii
artificial intelligence
data analysis
study protocol