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Mediators of the association between educational attainment and type 2 diabetes mellitus: a two-step multivariable Mendelian randomisation study.

Jia ZhangZekai ChenKatri PärnaSander K R van ZonHarold SniederChris H L Thio
Published in: Diabetologia (2022)
These results support a potentially causal protective effect of EA against type 2 diabetes, with considerable mediation by a number of modifiable risk factors. Interventions on these factors thus have the potential of substantially reducing the burden of type 2 diabetes attributable to low EA.
Keyphrases
  • risk factors
  • type diabetes
  • glycemic control
  • physical activity
  • cardiovascular disease
  • insulin resistance
  • social support
  • metabolic syndrome
  • human health
  • skeletal muscle
  • cardiovascular risk factors
  • climate change